Britta Siegmund Selected Research

pumafentrine

1/2013

The selective phosphodiesterase 4 inhibitor roflumilast and phosphodiesterase 3/4 inhibitor pumafentrine reduce clinical score and TNF expression in experimental colitis in mice.

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Britta Siegmund Research Topics

Disease

36	Inflammation (Inflammations) 01/2022 - 06/2002
30	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2022 - 02/2004
29	Crohn Disease (Crohn's Disease) 11/2022 - 07/2002
24	Colitis 01/2022 - 06/2002
19	Ulcerative Colitis 11/2022 - 01/2009
16	Neoplasms (Cancer) 01/2021 - 03/2002
5	Necrosis 01/2021 - 10/2002
5	Pain (Aches) 09/2019 - 01/2013
4	Infections 11/2022 - 01/2014
4	COVID-19 06/2022 - 08/2020
4	Hemorrhage 01/2022 - 01/2013
4	Hepatitis 10/2021 - 01/2002
4	Celiac Disease (Celiac Sprue) 09/2021 - 05/2015
4	Hyperplasia 01/2018 - 06/2004
4	Obesity 07/2008 - 01/2002
3	Proctitis 11/2022 - 01/2019
3	Abdominal Pain (Pain, Abdominal) 09/2019 - 02/2016
3	Neuroendocrine Tumors (Neuroendocrine Tumor) 01/2018 - 04/2015
3	Diarrhea 10/2017 - 02/2011
3	Pathologic Constriction (Stenosis) 05/2016 - 04/2015
3	Pancreatitis 01/2016 - 06/2008
3	Body Weight (Weight, Body) 01/2013 - 10/2004
3	Carcinogenesis 05/2011 - 08/2009
2	Wounds and Injuries (Trauma) 11/2022 - 01/2019
2	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 06/2022 - 01/2022
2	Sclerosing Cholangitis 04/2022 - 10/2021
2	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 01/2022 - 01/2017
2	Critical Illness (Critically Ill) 01/2022 - 09/2014
2	Fibrosis (Cirrhosis) 10/2021 - 07/2017
2	Ileitis 01/2021 - 07/2007
2	Liver Cirrhosis (Hepatic Cirrhosis) 08/2020 - 01/2019
2	Cholangitis 03/2020 - 01/2018
2	Fistula 01/2020 - 04/2016
2	Chronic Pain 09/2019 - 02/2016
2	Atrophy 03/2017 - 08/2011
2	Pancytopenia 12/2015 - 04/2015
2	Weight Loss (Weight Reduction) 01/2013 - 06/2008
1	Cytokine Release Syndrome 06/2022
1	Respiratory Insufficiency (Respiratory Failure) 06/2022
1	Ileal Diseases 01/2022
1	Pulmonary Aspergillosis 01/2022

Drug/Important Bio-Agent (IBA)

22	CytokinesIBA 06/2022 - 03/2002
9	LeptinIBA 12/2019 - 01/2002
7	InterleukinsIBA 01/2022 - 02/2004
7	Proteins (Proteins, Gene)FDA Link 01/2021 - 09/2004
6	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2022 - 01/2009
6	AntibodiesIBA 01/2020 - 09/2004
6	Dextran SulfateIBA 09/2019 - 06/2002
6	Histone Deacetylase InhibitorsIBA 01/2019 - 01/2005
6	Interleukin-18 (Interleukin 18)IBA 03/2010 - 07/2002
5	vedolizumabIBA 11/2021 - 01/2017
5	Biomarkers (Surrogate Marker)IBA 10/2021 - 07/2007
5	AdipokinesIBA 01/2019 - 06/2013
4	Pharmaceutical PreparationsIBA 11/2022 - 04/2015
4	Interleukin-10 (Interleukin 10)IBA 01/2022 - 10/2004
4	Biological ProductsIBA 01/2021 - 07/2017
4	SteroidsIBA 02/2019 - 01/2016
4	Histone Deacetylases (Histone Deacetylase)IBA 01/2019 - 03/2002
4	Azathioprine (Imuran)FDA LinkGeneric 05/2017 - 12/2015
4	AntigensIBA 05/2015 - 08/2011
3	sodium sulfate (sodium bisulfate)FDA LinkGeneric 11/2021 - 01/2013
3	Dextrans (Dextran)FDA Link 11/2021 - 01/2013
3	Adalimumab (Humira)FDA Link 01/2021 - 12/2015
3	EnzymesIBA 01/2021 - 01/2013
3	Anti-Bacterial Agents (Antibiotics)IBA 03/2020 - 02/2011
3	LipopolysaccharidesIBA 09/2015 - 03/2002
3	Interleukin-6 (Interleukin 6)IBA 02/2014 - 03/2011
2	Budesonide (Pulmicort)FDA LinkGeneric 11/2022 - 01/2019
2	Interleukin-22 (IL-22)IBA 01/2022 - 01/2021
2	Peptides (Polypeptides)IBA 01/2022 - 01/2019
2	Infliximab (Remicade)FDA Link 01/2021 - 01/2021
2	Leukocyte L1 Antigen Complex (Calgranulin)IBA 01/2021 - 01/2019
2	Ustekinumab (CNTO 1275)FDA Link 01/2020 - 01/2018
2	Interleukin-12 (IL 12)IBA 01/2020 - 06/2008
2	Mesalamine (Mesalazine)FDA LinkGeneric 01/2019 - 01/2013
2	Glutens (Glutelin)IBA 03/2017 - 05/2015
2	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 09/2015 - 03/2011
2	Phenobarbital (Luminal)FDA Link 01/2015 - 01/2014
2	Drinking WaterIBA 01/2013 - 02/2004
2	InflammasomesIBA 07/2011 - 03/2010
2	givinostat hydrochlorideIBA 05/2011 - 01/2005
2	Hydroxamic Acids (Hydroxamic Acid)IBA 05/2011 - 04/2006
2	InterferonsIBA 03/2011 - 01/2011
2	Interleukin-1 (Interleukin 1)IBA 01/2008 - 06/2004
2	Sulfonic AcidsIBA 04/2006 - 06/2002
2	Interferon Regulatory Factor-1 (Interferon Regulatory Factor 1)IBA 09/2004 - 03/2002
2	pralnacasanIBA 02/2004 - 07/2002
2	IceIBA 02/2004 - 07/2002
1	HLA-B27 Antigen (HLA B27 Antigen)IBA 10/2022
1	imdevimabIBA 06/2022
1	casirivimab and imdevimab drug combinationIBA 06/2022
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2022
1	Dexamethasone (Maxidex)FDA LinkGeneric 01/2022

Therapy/Procedure

33	Therapeutics 11/2022 - 11/2005
3	Lasers (Laser) 01/2022 - 12/2014
3	Gluten-Free Diet 01/2022 - 01/2017
3	Transcranial Direct Current Stimulation 09/2019 - 02/2016
2	Renal Replacement Therapy (Therapies, Renal Replacement) 01/2022 - 04/2021
2	Critical Care (Surgical Intensive Care) 01/2022 - 03/2020
2	Oral Administration 05/2011 - 04/2006